Outside of the health risks I don't see the issue with enhancers at all tbh
Said as someone who has never used them for daygame
If gaming on drugs gets you more approaches, conversations, numbers, dates, lays, then you're getting more quality and quantity of interactions in the time spent, which gives you more experience. A lot of social/dating skills are a snowball effect, where more success precipitates even more success, so even if drugged-you skills transfer inefficiently to sober-you, it's probably still more than you'd get from trying to sober rawdog the whole thing
It also really really helps destroy limiting beliefs, like @Rice getting a ton of success on phenibut and realizing just how much of what his brain was normally telling him during daygame was bullshit
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also independently of the whole developing your skills thing - don't we want to GET LAID? if taking drugs gets you LAID more then why not do it just for that effect alone?